US 20130053332A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2013/0053332 A1 Mithen (43) Pub. Date: Feb. 28, 2013 (54) US
Patent Application Publication Feb. 28, 2013 Sheet 10 0f 19 US 2013/0053332 A1 1.397 13s? A 23.4? B Q‘ U) C 2 E 23.40 k L .0 5 snag a 8D 3096 .35‘ U’)
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Patent Application Publication Feb. 28, 2013 Sheet 12 0f 19 US 2013/0053332 A1 P410001 P410001 0 0 Al TGFb’i (2 ng/mi) SF (2 0M) DTT (10 mM) 45 4.2 Ea
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Patent Application Publication Feb. 28, 2013 Sheet 14 0f 19 US 2013/0053332 A1 Primers and probes for genotype analysis. Gene Sequence Primer & pr
Patent Application Publication Feb. 28, 2013 Sheet 15 0f 19 US 2013/0053332 A1 p~EGFR (Ty/r1065) in BPHi ceHs ~ 10 min 10 ng/ul EGF & 10 MW SF - G
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Patent Application Publication Feb. 28, 2013 Sheet 18 0f 19 US 2013/0053332 A1 BPHA Cells J? Growth factovs Contra! EGF iNSULIN Contro! SF 211M SF 10p
Patent Application Publication Feb. 28, 2013 Sheet 19 0f 19 US 2013/0053332 A1 Fig‘ 21
Patent Application Publication Feb. 28, 2013 Sheet 2 0f 19 US 2013/0053332 A1 CVD risk <1’10% over next 10 years m %a De n/mV: mm km .66 rn r WW C0
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Patent Application Publication Feb. 28, 2013 Sheet 6 0f 19 US 2013/0053332 A1 Training set Test set
Patent Application Publication Feb. 28, 2013 Sheet 7 0f 19 US 2013/0053332 A1 400» 300 200J Number of probes 100~ Peas 160 Number of probes
Patent Application Publication Feb. 28, 2013 Sheet 8 0f 19 US 2013/0053332 A1 25 A 20~ ‘$3 15 X é‘ % g 10 51 G M‘ I AMA “\QE 0 2 4 6 8 '10 Time
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