Vulcan-Hart ML-052200 Bedienungsanleitung

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US
20130053332A1
(19)
United
States
(12)
Patent
Application
Publication
(10)
Pub.
No.:
US
2013/0053332
A1
Mithen
(43)
Pub.
Date:
Feb.
28,
2013
(54)
USE
Publication
Classi?cation
_
. .
.
(51)
Int.
Cl.
(75)
Inventor.
Richard
Mithen,
NorW1ch
(GB)
A
61K
31/7028
(200601)
A61K
31/26
(2006.01)
. _
A61P
9/10
(2006.01)
(73)
Assignee.
PLANT
BIOSCIENCE
LIMITED,
A611,
3/02
(2006.01)
NOrWwh
(GB)
A61P
29/00
(2006.01)
A61P
7/02
(2006.01)
(21)
Appl.
No.:
13/518,777
A61P
9/12
(2006.01)
A61P
3/06
(2006.01)
(22)
PCT
Filed:
Dec.
23,
2010
A61P
9/00
(200601)
A61P
9/04
(2006.01)
(86)
PCT
NO;
PCT/GB2010/052200
(52)
US.
Cl.
........................................
..
514/24;
514/514
§
371
(0(1).
)
t.
t.
AIBtSTtRACT
.t.
. .
_
e
presen
inven
ion
re
a
es
0
a
composi
ion
comprising
a
(2)’
(4)
Date‘
NOV‘
16’
2012
high
glucosinolate
Cruciferous
vegetable
(such
as
a
high
glu
_ _ _ _ _
cosinolate
broccoli)
having
a
high
level
of
glucosinolate
and/
(30)
Forelgn
APPhcatmn
Prlorlty
Data
or
at
least
one
derivative
thereof
for
use
in
the
treatment
or
prevention
of
a
cardiovascular
disease
or
foruse
in
promoting
Dec.
23,
2009
(GB)
.................................
..
09225053
heart
and/or
cardiovascular
health.
Seitenansicht 0
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Inhaltsverzeichnis

Seite 1 - 20130053332A1

US 20130053332A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2013/0053332 A1 Mithen (43) Pub. Date: Feb. 28, 2013 (54) US

Seite 3 - 345678911)

Patent Application Publication Feb. 28, 2013 Sheet 10 0f 19 US 2013/0053332 A1 1.397 13s? A 23.4? B Q‘ U) C 2 E 23.40 k L .0 5 snag a 8D 3096 .35‘ U’)

Seite 4 - 1\OO/;20%

Patent Application Publication Feb. 28, 2013 Sheet 11 0f 19 US 2013/0053332 A1 v»! 1085 858.4 19 - 1021.4 Intensity 1 1 1 11' 1.01.111 Mu / "

Seite 5 - \'Augmentation

Patent Application Publication Feb. 28, 2013 Sheet 12 0f 19 US 2013/0053332 A1 P410001 P410001 0 0 Al TGFb’i (2 ng/mi) SF (2 0M) DTT (10 mM) 45 4.2 Ea

Seite 6

Patent Application Publication Feb. 28, 2013 Sheet 13 0f 19 US 2013/0053332 A1 33; A82 . ,. a 6.6V . A39 A£ AIELV wcm?wkotzw 5035 M10 k E0 + + £10k .w

Seite 7 - Training

Patent Application Publication Feb. 28, 2013 Sheet 14 0f 19 US 2013/0053332 A1 Primers and probes for genotype analysis. Gene Sequence Primer & pr

Seite 8

Patent Application Publication Feb. 28, 2013 Sheet 15 0f 19 US 2013/0053332 A1 p~EGFR (Ty/r1065) in BPHi ceHs ~ 10 min 10 ng/ul EGF & 10 MW SF - G

Seite 9 - 2013/0053332

US 2013/0053332 A1 , wxmmiwwmw I L-B Feb. 28, 2013 Sheet 16 0f 19 Moscow. 500~ 400* 300~ 200* 100" O 8 24mm Patent Application Publication

Seite 11

Patent Application Publication Feb. 28, 2013 Sheet 18 0f 19 US 2013/0053332 A1 BPHA Cells J? Growth factovs Contra! EGF iNSULIN Contro! SF 211M SF 10p

Seite 13 - P410001

Patent Application Publication Feb. 28, 2013 Sheet 19 0f 19 US 2013/0053332 A1 Fig‘ 21

Seite 23

Patent Application Publication Feb. 28, 2013 Sheet 2 0f 19 US 2013/0053332 A1 CVD risk <1’10% over next 10 years m %a De n/mV: mm km .66 rn r WW C0

Seite 34

Patent Application Publication SBP SBP SBP 180 160 140 ‘I20 160 ‘580 160 140 120 100 180 160 140 120 100 Non-smoker Feb. 28, 2013 Sheet 3 0f 19 US 201

Seite 43

Patent Application Publication Feb. 28, 2013 Sheet 4 0f 19 US 2013/0053332 A1 FIGURE 3 Brie? Study Outiine Sampies [ nscaun'mwjr J "Mid stre

Seite 45

Patent Application Publication Feb. 28, 2013 Sheet 6 0f 19 US 2013/0053332 A1 Training set Test set

Seite 46

Patent Application Publication Feb. 28, 2013 Sheet 7 0f 19 US 2013/0053332 A1 400» 300 200J Number of probes 100~ Peas 160 Number of probes

Seite 47

Patent Application Publication Feb. 28, 2013 Sheet 8 0f 19 US 2013/0053332 A1 25 A 20~ ‘$3 15 X é‘ % g 10 51 G M‘ I AMA “\QE 0 2 4 6 8 '10 Time

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